Phenacetin
Phenacetin
Phenacetin (pronounced: /fɪˈnæsɪtɪn/) is a pain-relieving and fever-reducing drug, which was widely used between its introduction in 1887 and the 1983 ban imposed by the FDA.
Etymology
The term "Phenacetin" is derived from the chemical structure of the compound, which is an acetanilide derivative with a phenyl group attached.
Usage
Phenacetin was widely used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to its metabolite para-aminophenol and its associated oxidative stress. It was one of the first painkillers that was not derived from opium while at the same time being absent of anti-inflammatory qualities.
Synthesis
Phenacetin can be synthesized by acetylation of para-phenetidine, in a process that can be carried out in a home laboratory setting.
Related Terms
- Analgesic: A class of drugs used to relieve pain.
- Nephropathy: A term that refers to kidney disease or damage.
- Para-aminophenol: A compound that is a metabolite of phenacetin and is implicated in phenacetin-induced nephropathy.
- Para-phenetidine: A compound used in the synthesis of phenacetin.
- Opium: A narcotic drug that is very potent and addictive, used primarily in the treatment of pain.
External links
- Medical encyclopedia article on Phenacetin
- Wikipedia's article - Phenacetin
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