Lornoxicam
Nonsteroidal anti-inflammatory drug
Lornoxicam | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | |
CAS Number | |
PubChem | |
DrugBank | |
ChemSpider | |
KEGG |
Lornoxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation in various conditions. It is part of the oxicam class of NSAIDs, which also includes drugs like piroxicam and meloxicam.
Pharmacology
Lornoxicam works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are responsible for the conversion of arachidonic acid to prostaglandins, which are mediators of inflammation and pain. By reducing the production of prostaglandins, lornoxicam alleviates symptoms of pain and inflammation.
Chemical Structure
Lornoxicam is chemically known as 6-chloro-4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide. It is a yellow crystalline powder that is practically insoluble in water.
Pharmacokinetics
Lornoxicam is rapidly absorbed after oral administration, with peak plasma concentrations occurring approximately 1 to 2 hours post-dose. It has a half-life of about 3 to 5 hours, which is relatively short compared to other NSAIDs. Lornoxicam is extensively metabolized in the liver, primarily by cytochrome P450 enzymes, and is excreted mainly in the urine.
Clinical Uses
Lornoxicam is indicated for the management of acute mild to moderate pain, such as postoperative pain, and for the treatment of chronic inflammatory conditions like rheumatoid arthritis and osteoarthritis.
Side Effects
Common side effects of lornoxicam include gastrointestinal disturbances such as nausea, vomiting, and dyspepsia. Like other NSAIDs, it may increase the risk of gastrointestinal bleeding, ulceration, and perforation. It can also cause renal impairment and hypertension.
Contraindications
Lornoxicam is contraindicated in patients with known hypersensitivity to the drug, those with active peptic ulcer disease, and in individuals with severe hepatic or renal impairment. It should be used with caution in patients with a history of asthma or allergic reactions to other NSAIDs.
Drug Interactions
Lornoxicam may interact with other medications such as anticoagulants, increasing the risk of bleeding. It can also interact with antihypertensive drugs, potentially reducing their effectiveness.
Related pages
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD