Indometacin farnesil
Indometacin farnesil is a pharmaceutical compound recognized by its INN. Acting as a prodrug, it serves as a precursor to the more widely recognized non-steroidal anti-inflammatory drug (NSAID) known as indometacin.
Overview
The primary rationale behind the creation of indometacin farnesil was to circumvent some of the adverse effects commonly associated with indometacin. This was achieved by esterifying the carboxyl group present on indometacin using farnesol, a process that can reduce the potential for certain side-effects.
Approval and Availability
Japan
Indometacin farnesil received its initial approval in Japan in 1991. It is commercially available in the country under the trade name Infree.
Indonesia
In addition to Japan, indometacin farnesil is also available in Indonesia. Here, the medication can be found under the trade name Dialon.
Pharmacological Mechanism
As a prodrug, indometacin farnesil is biologically inactive in its administered form. Once inside the body, however, it is metabolized to release the active NSAID, indometacin. This transformation allows for the therapeutic effects of indometacin to be realized, while the esterification with farnesol aims to mitigate the drug's side-effects.
See Also
External links
| Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA) |
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