Aminophenazone

Aminophenazone

• 

  2D Skeletal Structure of Aminophenazone

• 

  3D Ball-and-Stick Model of Aminophenazone

Aminophenazone

Aminophenazone, also known as aminopyrine, is a non-opioid analgesic and antipyretic drug that was widely used in the past for its pain-relieving and fever-reducing properties. It belongs to the class of pyrazolone derivatives and was first introduced in the early 20th century.

Chemical Structure and Properties

Aminophenazone is a derivative of phenazone, with the chemical formula C13H17N3O. It is characterized by the presence of an amino group attached to the pyrazolone ring. The compound is a white crystalline powder that is soluble in water and alcohol.

Pharmacology

Aminophenazone works by inhibiting the synthesis of prostaglandins, which are compounds involved in the mediation of pain and inflammation. It exerts its effects primarily through the inhibition of the cyclooxygenase (COX) enzymes, similar to other non-steroidal anti-inflammatory drugs (NSAIDs).

Medical Uses

Historically, aminophenazone was used to treat a variety of conditions, including:

• Headache
• Rheumatic fever
• Arthritis
• Fever

However, due to safety concerns, its use has been largely discontinued in many countries.

Safety and Side Effects

Aminophenazone has been associated with several adverse effects, the most significant being agranulocytosis, a potentially life-threatening condition characterized by a severe reduction in the number of white blood cells. This risk led to the withdrawal of aminophenazone from the market in many regions.

Other side effects may include:

• Allergic reactions
• Gastrointestinal disturbances
• Skin rash

Regulatory Status

Due to the risk of agranulocytosis and other side effects, aminophenazone is no longer widely used and has been replaced by safer alternatives such as paracetamol and ibuprofen. In some countries, its use is restricted to specific cases under medical supervision.

Related Pages

• Analgesic
• Antipyretic
• Non-steroidal anti-inflammatory drug
• Prostaglandin
• Cyclooxygenase

This article is a stub related to pharmacology. You can help WikiMD by expanding it!