Tiaprofenic acid
An article about the nonsteroidal anti-inflammatory drug Tiaprofenic acid
Tiaprofenic acid
Tiaprofenic acid is a nonsteroidal anti-inflammatory drug (NSAID) used for its analgesic and anti-inflammatory properties. It is commonly prescribed for the treatment of rheumatoid arthritis, osteoarthritis, and other musculoskeletal disorders.
Pharmacology
Tiaprofenic acid works by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation and pain, and by reducing their production, tiaprofenic acid alleviates symptoms associated with inflammatory conditions.
Mechanism of action
The primary mechanism of action of tiaprofenic acid is the non-selective inhibition of COX-1 and COX-2 enzymes. This inhibition leads to decreased formation of prostaglandins, which are responsible for causing inflammation, pain, and fever.
Clinical use
Tiaprofenic acid is indicated for the management of pain and inflammation in conditions such as:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute musculoskeletal disorders
Side effects
As with other NSAIDs, tiaprofenic acid can cause a range of side effects. Common side effects include:
- Gastrointestinal disturbances such as nausea, vomiting, and dyspepsia
- Headache
- Dizziness
More serious side effects may include:
Contraindications
Tiaprofenic acid is contraindicated in patients with:
- Known hypersensitivity to tiaprofenic acid or other NSAIDs
- History of asthma attacks, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer disease
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Contributors: Prab R. Tumpati, MD
