Para-Fluorophenylpiperazine

Para-Fluorophenylpiperazine

Chemical structure of para-Fluorophenylpiperazine

Para-Fluorophenylpiperazine (pFPP) is a chemical compound belonging to the piperazine class. It is a derivative of phenylpiperazine and is known for its psychoactive properties. pFPP has been used in scientific research and has also appeared in the recreational drug market.

Chemical Structure and Properties

Para-Fluorophenylpiperazine is characterized by the presence of a fluorine atom at the para position of the phenyl ring attached to the piperazine moiety. This structural modification influences its pharmacological activity and receptor binding profile.

The molecular formula of pFPP is C₁₀H₁₃FN₂, and it has a molecular weight of 180.22 g/mol. The compound is typically synthesized through the reaction of piperazine with para-fluorobenzene.

Pharmacology

pFPP acts primarily as a serotonin receptor agonist, with a particular affinity for the 5-HT_1A and 5-HT_2A receptors. This activity is responsible for its psychoactive effects, which can include mood enhancement, mild euphoria, and altered perception.

The compound's interaction with serotonin receptors is similar to that of other phenylpiperazine derivatives, such as mCPP and TFMPP. However, the presence of the fluorine atom in pFPP alters its potency and selectivity.

Uses and Effects

In research settings, para-Fluorophenylpiperazine is used to study the effects of serotonin receptor agonists on the central nervous system. It serves as a tool for understanding the role of serotonin in mood regulation and other neurological processes.

Recreationally, pFPP has been used as a designer drug, often found in "party pills" or "herbal highs." Users report effects such as increased sociability, enhanced mood, and mild hallucinations. However, it can also cause adverse effects like anxiety, nausea, and headaches.

Legal Status

The legal status of para-Fluorophenylpiperazine varies by country. In some regions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. In others, it remains unregulated, although its sale and distribution may be restricted under analog laws.

Safety and Toxicity

The safety profile of pFPP is not well-established, and its long-term effects are not fully understood. Acute toxicity is generally low, but high doses can lead to severe side effects, including serotonin syndrome, a potentially life-threatening condition.

Related Compounds

Para-Fluorophenylpiperazine is part of a broader class of phenylpiperazine derivatives, which includes:

• mCPP (meta-Chlorophenylpiperazine)
• TFMPP (Trifluoromethylphenylpiperazine)
• BZP (Benzylpiperazine)

These compounds share similar pharmacological properties and are often studied together in research on serotonin receptor agonists.

Related Pages

• Piperazine
• Serotonin receptor
• Designer drug

3D model of para-Fluorophenylpiperazine