Piberaline

Piberaline

Piberaline is a pharmacological agent that belongs to the class of antidepressants. It is a serotonin antagonist and reuptake inhibitor (SARI) that was developed in the 1970s but was never marketed.

History

Piberaline was first synthesized in the 1970s as part of a series of compounds aimed at developing new antidepressant medications. Despite showing promise in early trials, it was never brought to market for reasons that remain unclear.

Pharmacology

As a serotonin antagonist and reuptake inhibitor (SARI), piberaline works by blocking the reuptake of serotonin, a neurotransmitter that is involved in mood regulation. This increases the amount of serotonin available in the brain, which can help to alleviate symptoms of depression.

Clinical Trials

Early clinical trials of piberaline showed that it had a similar efficacy to other antidepressants available at the time. However, it was also found to have a relatively high incidence of side effects, which may have contributed to its lack of commercial success.

Side Effects

The most common side effects of piberaline include nausea, dizziness, and dry mouth. In rare cases, it can also cause more serious side effects such as hallucinations and severe allergic reactions.

Current Status

Despite its early promise, piberaline is not currently available for use as a medication. However, it continues to be studied in the field of pharmacology, particularly in relation to its potential use in the treatment of depression and other mood disorders.

See Also

• Serotonin antagonist and reuptake inhibitor
• Antidepressant
• Depression

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