Meclocycline

Meclocycline is a tetracycline antibiotic used primarily in the treatment of various bacterial infections. It is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria. Meclocycline is also used in the treatment of acne, due to its ability to inhibit the growth of certain bacteria that contribute to the development of acne.

History

Meclocycline was first synthesized in the 1960s as part of a larger effort to develop new tetracycline antibiotics. It was found to have a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, making it a valuable addition to the tetracycline class of antibiotics.

Mechanism of Action

Like other tetracycline antibiotics, Meclocycline works by inhibiting protein synthesis in bacteria. It does this by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl-tRNA to the ribosome. This prevents the bacteria from making proteins, which they need to grow and multiply.

Uses

Meclocycline is used to treat a variety of bacterial infections, including those caused by Staphylococcus, Streptococcus, and E. coli. It is also used to treat acne, as it is effective against the bacteria Propionibacterium acnes, which contributes to the development of acne.

Side Effects

Common side effects of Meclocycline include nausea, vomiting, diarrhea, and photosensitivity. In rare cases, it can cause more serious side effects, such as hepatotoxicity or C. difficile infection.

See Also

• Tetracycline antibiotics
• Bacterial infection
• Acne

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Types of antibacterials

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  Meclocycline chemical structure
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  Meclocycline 3D ball model