Lenampicillin
Lenampicillin is an antibiotic in the penicillin group of drugs. It is used to treat many different types of infections caused by bacteria, such as ear infections, bladder infections, pneumonia, gonorrhea, and E. coli or salmonella infection.
Chemical Structure
Lenampicillin is a prodrug of ampicillin with improved oral bioavailability. It is used in the form of lenampicillin hydrochloride. The chemical structure of lenampicillin includes a phenyl group, making it a semi-synthetic penicillin.
Mechanism of Action
Like all penicillins, lenampicillin works by inhibiting the formation of bacterial cell walls. It does this by binding to penicillin-binding proteins located inside the bacterial cell wall. This inhibits the third and final stage of bacterial cell wall synthesis, which ultimately leads to cell lysis.
Side Effects
Common side effects of lenampicillin include nausea, vomiting, diarrhea, and skin rash. In rare cases, it can cause serious side effects like an allergic reaction, liver damage, and blood disorders.
Interactions
Lenampicillin may interact with other medications, including methotrexate, probenecid, and other antibiotics. It's important to inform your healthcare provider about all the medications you're currently taking to avoid potential interactions.
Precautions
Before taking lenampicillin, tell your doctor if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
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Contributors: Prab R. Tumpati, MD