Penicillin-binding proteins

Penicillin-binding proteins (PBPs) are a group of proteins that are characterized by their affinity to and binding of penicillin. They are a crucial component of the bacterial cell wall synthesis.

Pronunciation

Penicillin-binding proteins: /ˌpɛnɪˈsɪlɪn ˈbaɪndɪŋ ˈproʊtiːnz/

Etymology

The term "Penicillin-binding proteins" is derived from the ability of these proteins to bind penicillin, a group of antibiotics originally derived from Penicillium fungi.

Function

Penicillin-binding proteins are involved in the final stages of constructing the bacterial cell wall, which is essential for maintaining the shape and integrity of the cell. They catalyze a number of processes, including the cross-linking of the peptidoglycan layer.

Types

There are several types of PBPs, each with a specific role in the synthesis of the cell wall. These include PBP1, PBP2, PBP3, and PBP4.

Clinical significance

PBPs are the target of many antibiotics, including penicillin and other beta-lactam antibiotics. These antibiotics inhibit the function of PBPs, preventing the synthesis of the bacterial cell wall and leading to cell death.

Related terms

Peptidoglycan: A polymer consisting of sugars and amino acids that forms a mesh-like layer outside the plasma membrane of most bacteria, providing them with structural support and protection.
Beta-lactam antibiotics: A class of broad-spectrum antibiotics, consisting of all antibiotic agents that contain a beta-lactam ring in their molecular structures.
Penicillin: An antibiotic derived from Penicillium fungi, used to treat a wide range of bacterial infections.

External links

Medical encyclopedia article on Penicillin-binding proteins
Wikipedia's article - Penicillin-binding proteins

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Penicillin-binding proteins