Isepamicin
Isepamicin is an aminoglycoside antibiotic that is used in the treatment of various types of bacterial infections. It was first discovered in the 1970s and is derived from gentamicin.
History
Isepamicin was first discovered in the 1970s by the Japanese pharmaceutical company Nippon Kayaku. It was derived from gentamicin, a type of aminoglycoside antibiotic, through the process of chemical modification. The aim was to create an antibiotic that was less toxic and more effective against resistant bacteria.
Mechanism of Action
Isepamicin works by binding to the 30S ribosomal subunit of the bacteria, which interferes with protein synthesis. This prevents the bacteria from growing and multiplying, thereby stopping the infection.
Uses
Isepamicin is used to treat a variety of bacterial infections, including those caused by Gram-negative bacteria such as Pseudomonas aeruginosa and Escherichia coli. It is also used to treat infections caused by Staphylococcus aureus and other Gram-positive bacteria.
Side Effects
Like other aminoglycoside antibiotics, isepamicin can have side effects. These can include kidney damage, hearing loss, and balance problems. However, these side effects are generally rare and isepamicin is considered to be less toxic than other aminoglycosides.
Resistance
Resistance to isepamicin can occur, and is usually due to the production of aminoglycoside modifying enzymes by the bacteria. These enzymes can modify the antibiotic, preventing it from binding to the 30S ribosomal subunit and thereby rendering it ineffective.
See Also
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