Cefamandole

An article about the antibiotic Cefamandole

Cefamandole

Cefamandole is a cephalosporin antibiotic used to treat a variety of bacterial infections. It is a second-generation cephalosporin, which means it has a broader spectrum of activity compared to first-generation cephalosporins.

Mechanism of Action

Cefamandole works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which leads to the interruption of cell wall synthesis and ultimately causes bacterial cell death.

Pharmacokinetics

Cefamandole is administered via intravenous or intramuscular injection. It is well-distributed throughout the body and achieves therapeutic concentrations in various tissues and fluids. The drug is primarily excreted by the kidneys, and its elimination half-life is approximately 1 hour.

Clinical Uses

Cefamandole is used to treat infections caused by susceptible strains of bacteria, including:

• Respiratory tract infections
• Urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections

Side Effects

Common side effects of cefamandole include:

• Allergic reactions such as rash and anaphylaxis
• Gastrointestinal disturbances like nausea and diarrhea
• Hematological effects such as eosinophilia and thrombocytopenia

Resistance

Bacterial resistance to cefamandole can occur through various mechanisms, including the production of beta-lactamase enzymes that degrade the antibiotic, and alterations in PBPs that reduce drug binding.

Related pages

• Cephalosporin
• Antibiotic resistance
• Beta-lactam antibiotic

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  Cefamandole