Ceftazidime
Ceftazidime
Ceftazidime (pronounced: sef-taz-i-deem) is a third-generation cephalosporin antibiotic used in the treatment of various bacterial infections.
Etymology
The term "Ceftazidime" is derived from the parent compound cephalosporin C, with "cef-" referring to the cephem nucleus, "-taz-" referring to the aminothiazole side chain, and "-idime" indicating the presence of a carboxyquinolone moiety.
Usage
Ceftazidime is primarily used to treat severe bacterial infections that are resistant to other antibiotics. It is particularly effective against Pseudomonas aeruginosa, a common cause of hospital-acquired infections.
Mechanism of Action
Ceftazidime works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. It binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall.
Side Effects
Common side effects of ceftazidime include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause serious allergic reactions.
Related Terms
- Cephalosporin: A class of antibiotics to which ceftazidime belongs.
- Pseudomonas aeruginosa: A bacterium against which ceftazidime is particularly effective.
- Penicillin-binding proteins: Proteins that ceftazidime targets to inhibit bacterial cell wall synthesis.
External links
- Medical encyclopedia article on Ceftazidime
- Wikipedia's article - Ceftazidime
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