Plazomicin
Plazomicin (pronounced: pla-zo-mi-cin) is an aminoglycoside antibiotic that is used to treat serious bacterial infections. It is a synthetic derivative of the aminoglycoside antibiotic sisomicin.
Etymology
The term "Plazomicin" is derived from the Greek words "plazo" meaning to mold or form, and "mycin" which is a common suffix for antibiotics, particularly those derived from Streptomyces species.
Pharmacology
Plazomicin works by binding to the bacterial 30S ribosomal subunit, which inhibits protein synthesis and results in bacterial cell death. It is particularly effective against Enterobacteriaceae, including multi-drug resistant strains.
Clinical Use
Plazomicin is used to treat complicated urinary tract infections (cUTIs), including pyelonephritis, caused by susceptible Enterobacteriaceae. It is also used in combination with other antibiotics to treat serious bacterial infections in patients who have limited or no alternative treatment options.
Side Effects
Common side effects of plazomicin include kidney damage, hearing loss, and vertigo. Less common but more serious side effects can include ototoxicity and nephrotoxicity.
Related Terms
- Aminoglycoside
- Antibiotic
- Sisomicin
- 30S ribosomal subunit
- Enterobacteriaceae
- Pyelonephritis
- Ototoxicity
- Nephrotoxicity
External links
- Medical encyclopedia article on Plazomicin
- Wikipedia's article - Plazomicin
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