Garenoxacin

Garenoxacin

Chemical structure of Garenoxacin

Garenoxacin is a quinolone antibiotic that is used to treat a variety of bacterial infections. It is a broad-spectrum antibiotic, effective against both Gram-positive and Gram-negative organisms. Garenoxacin is particularly noted for its activity against anaerobic bacteria and atypical bacteria.

Mechanism of Action

Garenoxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for bacterial DNA replication, transcription, repair, and recombination. By interfering with these enzymes, garenoxacin prevents the bacteria from multiplying and ultimately leads to their death.

Clinical Uses

Garenoxacin is used to treat a variety of infections, including:

• Respiratory tract infections
• Skin and soft tissue infections
• Urinary tract infections
• Intra-abdominal infections

Pharmacokinetics

Garenoxacin is well absorbed after oral administration, with a bioavailability of approximately 90%. It is widely distributed throughout the body, achieving therapeutic concentrations in various tissues and fluids. The drug is primarily excreted in the urine.

Side Effects

Common side effects of garenoxacin include:

• Nausea
• Diarrhea
• Headache
• Dizziness

Serious side effects, although rare, may include tendon rupture, QT interval prolongation, and hypersensitivity reactions.

Contraindications

Garenoxacin is contraindicated in patients with a known hypersensitivity to quinolones. Caution is advised in patients with a history of seizures or cardiac arrhythmias.

Related Pages

• Quinolone
• Antibiotic
• Bacterial infection