Cefmetazole

Cefmetazole
Cefmetazole.svg
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Cefmetazole is a beta-lactam antibiotic belonging to the cephalosporin class. It is used primarily in the treatment of bacterial infections, particularly those caused by Gram-negative bacteria.

Mechanism of Action

Cefmetazole works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which leads to the interruption of cell wall synthesis and ultimately causes bacterial cell death. This mechanism is similar to other beta-lactam antibiotics.

Pharmacokinetics

Cefmetazole is administered via intravenous or intramuscular injection. It is well-distributed throughout the body and achieves therapeutic concentrations in various tissues and fluids. The drug is primarily excreted unchanged in the urine, making it effective for treating urinary tract infections.

Clinical Uses

Cefmetazole is indicated for the treatment of a variety of infections, including:

• Urinary tract infections
• Respiratory tract infections
• Skin and soft tissue infections
• Intra-abdominal infections

Side Effects

Common side effects of cefmetazole include:

• Nausea
• Diarrhea
• Rash
• Allergic reactions

Serious side effects, although rare, may include:

• Anaphylaxis
• Clostridium difficile infection
• Hematologic abnormalities

Resistance

Bacterial resistance to cefmetazole can occur through various mechanisms, such as the production of beta-lactamase enzymes that degrade the antibiotic. Resistance can also arise from alterations in PBPs or decreased permeability of the bacterial cell wall.

Related pages

• Cephalosporin
• Antibiotic resistance
• Beta-lactam antibiotic

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  Cefmetazole