Kendomycin
Kendomycin is a polyketide antibiotic that was first isolated from the bacteria Streptomyces violaceoruber in 1997. It is known for its unique cage-like structure and its potent activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).
Structure and Synthesis
The structure of Kendomycin is characterized by a 6-6-5-6-6 pentacyclic system, which forms a cage-like structure. This complex structure has made the synthesis of Kendomycin a significant challenge for organic chemists. The first total synthesis of Kendomycin was reported in 2007, and since then, several other synthetic routes have been developed.
Biological Activity
Kendomycin exhibits potent antibacterial activity against a range of Gram-positive bacteria, including MRSA. It is also active against certain cancer cell lines, suggesting potential anticancer applications. The mechanism of action of Kendomycin is not fully understood, but it is thought to inhibit protein synthesis by binding to the ribosome.
Clinical Potential and Challenges
Despite its potent antibacterial and anticancer activity, the clinical development of Kendomycin has been hampered by its complex structure, which makes it difficult to synthesize on a large scale. However, ongoing research into new synthetic routes and analogs of Kendomycin could potentially overcome these challenges and pave the way for its use as a novel therapeutic agent.
See Also
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD
