Sulfamethoxypyridazine: Difference between revisions

Latest revision as of 16:27, 16 February 2025

Sulfamethoxypyridazine[edit]

Chemical structure of Sulfamethoxypyridazine

Sulfamethoxypyridazine is a sulfonamide antibiotic used in the treatment of various bacterial infections. It is a member of the sulfonamide class of drugs, which are synthetic antimicrobial agents that contain the sulfonamide group. Sulfamethoxypyridazine is known for its broad-spectrum activity against a variety of Gram-positive and Gram-negative bacteria.

Mechanism of Action[edit]

Sulfamethoxypyridazine works by inhibiting the bacterial enzyme dihydropteroate synthase, which is involved in the synthesis of folic acid. Folic acid is essential for bacterial growth and replication, as it is a precursor for the synthesis of nucleic acids. By blocking this enzyme, sulfamethoxypyridazine effectively halts bacterial growth, making it a bacteriostatic agent.

Clinical Uses[edit]

Sulfamethoxypyridazine is used to treat a variety of infections, including:

It is often used in combination with other antibiotics to enhance its efficacy and reduce the risk of resistance development.

Pharmacokinetics[edit]

Sulfamethoxypyridazine is well absorbed from the gastrointestinal tract when administered orally. It is distributed throughout the body and can cross the blood-brain barrier. The drug is metabolized in the liver and excreted primarily through the kidneys. Its half-life allows for convenient dosing schedules, often requiring administration only once or twice daily.

Side Effects[edit]

Common side effects of sulfamethoxypyridazine include:

Serious side effects, although rare, can include:

Patients with a known allergy to sulfonamides should avoid using this medication.

Related Pages[edit]

Types of antibacterials

@@ Line 1: / Line 1: @@
-'''Sulfamethoxypyridazine''' is a [[sulfonamide (medicine)|sulfonamide]] [[antibiotic]] used in the treatment of various [[bacterial infection|bacterial infections]]. It is a long-acting sulfonamide that is often used in veterinary medicine, but can also be used in humans.
+== Sulfamethoxypyridazine ==
-== History ==
+[[File:Sulfamethoxypyridazine.png|thumb|right|Chemical structure of Sulfamethoxypyridazine]]
-Sulfamethoxypyridazine was first synthesized in the 1940s as part of a larger effort to develop effective antibacterial agents. It is part of the [[sulfonamide (medicine)|sulfonamide]] class of antibiotics, which were among the first systemic antibacterial agents to be used in medicine.
+'''Sulfamethoxypyridazine''' is a [[sulfonamide]] [[antibiotic]] used in the treatment of various bacterial infections. It is a member of the sulfonamide class of drugs, which are synthetic antimicrobial agents that contain the sulfonamide group. Sulfamethoxypyridazine is known for its broad-spectrum activity against a variety of [[Gram-positive]] and [[Gram-negative]] bacteria.
 == Mechanism of Action ==
-Sulfamethoxypyridazine works by inhibiting the enzyme [[dihydropteroate synthase]], which is necessary for the synthesis of [[folic acid]]. Bacteria need folic acid to survive and reproduce, so by inhibiting its production, sulfamethoxypyridazine effectively kills the bacteria.
+Sulfamethoxypyridazine works by inhibiting the bacterial enzyme [[dihydropteroate synthase]], which is involved in the synthesis of [[folic acid]]. Folic acid is essential for bacterial growth and replication, as it is a precursor for the synthesis of [[nucleic acids]]. By blocking this enzyme, sulfamethoxypyridazine effectively halts bacterial growth, making it a bacteriostatic agent.
-== Uses ==
+== Clinical Uses ==
-Sulfamethoxypyridazine is used to treat a variety of bacterial infections, including [[urinary tract infection|urinary tract infections]], [[respiratory tract infection|respiratory tract infections]], and [[skin infection|skin infections]]. It is also used in veterinary medicine to treat infections in animals.
+Sulfamethoxypyridazine is used to treat a variety of infections, including:
+* [[Urinary tract infections]]
+* [[Respiratory tract infections]]
+* [[Gastrointestinal infections]]
+* [[Skin and soft tissue infections]]
+It is often used in combination with other antibiotics to enhance its efficacy and reduce the risk of resistance development.
+== Pharmacokinetics ==
+Sulfamethoxypyridazine is well absorbed from the gastrointestinal tract when administered orally. It is distributed throughout the body and can cross the [[blood-brain barrier]]. The drug is metabolized in the liver and excreted primarily through the kidneys. Its half-life allows for convenient dosing schedules, often requiring administration only once or twice daily.
 == Side Effects ==
-Like all medications, sulfamethoxypyridazine can cause side effects. These can include [[nausea]], [[vomiting]], [[diarrhea]], and [[allergic reaction|allergic reactions]]. In rare cases, it can cause serious side effects like [[anemia]], [[liver damage]], and [[kidney damage]].
+Common side effects of sulfamethoxypyridazine include:
-== See Also ==
+* [[Nausea]]
+* [[Vomiting]]
+* [[Diarrhea]]
+* [[Rash]]
-* [[Sulfonamide (medicine)|Sulfonamide]]
+Serious side effects, although rare, can include:
+* [[Stevens-Johnson syndrome]]
+* [[Agranulocytosis]]
+* [[Hepatotoxicity]]
+Patients with a known allergy to sulfonamides should avoid using this medication.
+== Related Pages ==
+* [[Sulfonamide (medicine)]]
 * [[Antibiotic]]
-* [[Bacterial infection]]
+* [[Bacterial resistance]]
+{{Antibiotics}}
-[[Category:Antibiotics]]
+[[Category:Sulfonamide antibiotics]]
-[[Category:Sulfonamides]]
-{{Antibiotics-stub}}
-{{medicine-stub}}