Lugdunin
Lugdunin is a cyclic peptide antibiotic that is produced by the bacteria Staphylococcus lugdunensis. It was discovered in 2016 by a team of researchers from the University of Tübingen in Germany. Lugdunin is notable for its ability to combat methicillin-resistant Staphylococcus aureus (MRSA), a type of bacteria that is resistant to many antibiotics.
Discovery
The discovery of Lugdunin was made by a team of researchers led by Andreas Peschel and Bernhard Krismer. The team was studying the microbiota of the human nose when they found that Staphylococcus lugdunensis, a bacteria commonly found in the human nose, was producing a substance that could kill Staphylococcus aureus. Further analysis revealed that this substance was a new antibiotic, which they named Lugdunin.
Structure and Synthesis
Lugdunin is a cyclic peptide, meaning it is a short chain of amino acids that forms a cyclic structure. It is synthesized by Staphylococcus lugdunensis through a nonribosomal peptide synthetase (NRPS) pathway. The NRPS pathway is a common method of peptide synthesis in bacteria and fungi, and is responsible for the production of many antibiotics.
Mechanism of Action
The exact mechanism of action of Lugdunin is not fully understood. However, it is known that Lugdunin is able to kill Staphylococcus aureus, including MRSA strains, by disrupting their cell membrane. This disruption leads to a loss of proton motive force, which is essential for the bacteria's survival.
Potential Applications
The discovery of Lugdunin has potential implications for the treatment of bacterial infections, particularly those caused by MRSA. However, as of 2021, Lugdunin has not yet been tested in humans, and further research is needed to determine its safety and efficacy.
See Also
| This article is a stub. You can help WikiMD by registering to expand it. |
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD
