Coumermycin A1
Coumermycin A1 is a coumarin-based antibiotic that is produced by the bacterium Streptomyces rishiriensis. It belongs to the aminocoumarin class of antibiotics and is known for its ability to inhibit DNA gyrase, an enzyme that is essential for DNA replication in bacteria.
Structure and Synthesis
Coumermycin A1 is a dimeric molecule, composed of two identical monomers linked by a magnesium ion. Each monomer consists of a coumarin core, a deoxyaminosugar moiety, and a hydroxyl-substituted aromatic ring. The synthesis of Coumermycin A1 involves several steps, including the formation of the coumarin core, the attachment of the deoxyaminosugar, and the coupling of the two monomers.
Mechanism of Action
The primary target of Coumermycin A1 is DNA gyrase, a type of topoisomerase that introduces negative supercoils into DNA. By binding to the gyrase, Coumermycin A1 prevents the enzyme from carrying out its function, thereby inhibiting DNA replication and leading to cell death.
Clinical Use and Resistance
Coumermycin A1 has been used in the treatment of various bacterial infections. However, the widespread use of this antibiotic has led to the emergence of resistant strains of bacteria. Resistance to Coumermycin A1 is typically conferred by mutations in the genes encoding DNA gyrase.
See Also
References
| This article is a stub. You can help WikiMD by registering to expand it. |
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD
