Morphine

Information about Morphine[edit]

Morphine is one of the natural plant alkaloids found in opium and is the prototype opiate, against which other derivatives are measured in terms of analgesic effects and side effects.

Liver safety of Morphine[edit]

Morphine has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.

Mechanism of action of Morphine[edit]

Morphine is a natural alkaloid that is derived from resin extracts from the seeds of the opium poppy, Papaver somniferum. Morphine has potent and profound analgesic effects and has been used in clinical medicine for almost two hundred years. Morphine acts by engagement in cell surface opiate receptors (predominant µ type receptors) that are found in the central nervous system, but also heart, lung, vascular and intestinal cells. Current indications are for severe pain, pre- and postoperative analgesia, control of pain from angina pectoris or acute myocardial infarction and therapy of pulmonary edema.

Dosage and administration for Morphine[edit]

Morphine is available in multiple formulations, including oral tablets and syrups, suppositories, and solutions for injection in multiple concentrations. The typical dose of morphine for analgesia in adults is 10 mg every 3 to 4 hours by the subcutaneous, intramuscular or intravenous route. Morphine is well absorbed orally, but has extensive and variable first pass metabolism, so that its effect orally is somewhat variable.

Side effects of Morphine[edit]

Side effects of opiates are many and include sedation, respiratory depression, confusion, euphoria, agitation, itching, abdominal bloating, nausea, vomiting and diarrhea.

DEA controlled substance classification of Morphine[edit]

Morphine is a controlled substance and classified as a Schedule II drug, indicating that it has medical usefulness, but also a high potential for physical and psychological dependency and abuse. Full and partial opiod agonists:

Opiate antagonists:

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Ad. Transform your health with W8MD Weight Loss, Sleep & MedSpa

Tired of being overweight?

Special offer:

Budget GLP-1 weight loss medications

Semaglutide starting from $29.99/week and up with insurance for visit of $59.99 and up per week self pay.
Tirzepatide starting from $45.00/week and up (dose dependent) or $69.99/week and up self pay

✔ Same-week appointments, evenings & weekends

Learn more:

Advertise on WikiMD

WikiMD Medical Encyclopedia

Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Translate this page: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian