Hydrocodone/ibuprofen: Difference between revisions

Latest revision as of 16:25, 16 February 2025

Hydrocodone/Ibuprofen[edit]

Hydrocodone/ibuprofen is a combination medication used to relieve moderate to severe pain. It combines the opioid analgesic hydrocodone with the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen. This combination is effective in managing pain by utilizing the synergistic effects of both components.

Pharmacology[edit]

Hydrocodone[edit]

Hydrocodone is a semi-synthetic opioid derived from codeine. It acts primarily on the central nervous system by binding to the mu-opioid receptor, which leads to analgesia, sedation, and euphoria. Hydrocodone is metabolized in the liver by the cytochrome P450 enzyme system, particularly CYP2D6 and CYP3A4, into active metabolites such as hydromorphone.

Ibuprofen[edit]

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation and pain. By reducing their production, ibuprofen decreases inflammation, pain, and fever.

Indications[edit]

Hydrocodone/ibuprofen is indicated for the short-term management of acute pain that is severe enough to require an opioid analgesic and for which alternative treatments are inadequate. It is often prescribed for conditions such as postoperative pain, injury-related pain, and severe musculoskeletal pain.

Dosage and Administration[edit]

The dosage of hydrocodone/ibuprofen is individualized based on the patient's needs, severity of pain, and response to treatment. It is typically administered orally, with the dosage adjusted to achieve adequate pain control while minimizing adverse effects. Patients are advised to take the medication with food or milk to reduce gastrointestinal discomfort.

Side Effects[edit]

Common side effects of hydrocodone/ibuprofen include:

Nausea
Vomiting
Dizziness
Drowsiness
Constipation

Serious side effects may include:

Respiratory depression
Hepatotoxicity
Gastrointestinal bleeding
Renal impairment

Contraindications[edit]

Hydrocodone/ibuprofen is contraindicated in patients with:

Known hypersensitivity to hydrocodone, ibuprofen, or any component of the formulation
Severe respiratory depression
Acute or severe bronchial asthma
Gastrointestinal bleeding or peptic ulcer disease
Severe renal or hepatic impairment

Related Pages[edit]

@@ Line 1: / Line 1: @@
-'''Hydrocodone/Ibuprofen''' is a medication that combines an opioid pain reliever (hydrocodone) with a nonsteroidal anti-inflammatory drug (ibuprofen). It is used to relieve acute pain, such as pain following dental or surgical procedures.
+== Hydrocodone/Ibuprofen ==
-==Etymology==
+[[File:Hydrocodonebtibu75200.jpeg|thumb|right|Chemical structure of Hydrocodone]]
-The term "hydrocodone" is derived from two words: "hydro" is a prefix meaning water, and "codone" is derived from codeine, a type of narcotic. "Ibuprofen" is derived from the words "isobutyl", "phenyl", and "propionic acid", which describe its chemical structure.
-==Pharmacology==
+'''Hydrocodone/ibuprofen''' is a combination medication used to relieve moderate to severe pain. It combines the opioid analgesic [[hydrocodone]] with the nonsteroidal anti-inflammatory drug (NSAID) [[ibuprofen]]. This combination is effective in managing pain by utilizing the synergistic effects of both components.
-[[Hydrocodone]] is a semi-synthetic opioid derived from codeine. It works by binding to the mu-opioid receptors in the brain, which are responsible for pain perception. [[Ibuprofen]], on the other hand, works by inhibiting the production of prostaglandins, substances in the body that cause inflammation and pain.
-==Indications==
+== Pharmacology ==
-Hydrocodone/Ibuprofen is indicated for the short-term management of acute pain severe enough to require an opioid analgesic and where alternative treatments are inadequate.
-==Contraindications==
+=== Hydrocodone ===
-This medication is contraindicated in patients with significant respiratory depression, acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment, known or suspected gastrointestinal obstruction, and hypersensitivity to hydrocodone or ibuprofen.
-==Side Effects==
+[[Hydrocodone]] is a semi-synthetic opioid derived from codeine. It acts primarily on the central nervous system by binding to the [[mu-opioid receptor]], which leads to analgesia, sedation, and euphoria. Hydrocodone is metabolized in the liver by the cytochrome P450 enzyme system, particularly CYP2D6 and CYP3A4, into active metabolites such as [[hydromorphone]].
-Common side effects of Hydrocodone/Ibuprofen include nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness. Serious side effects may include slow/shallow breathing, severe drowsiness/difficulty waking up, confusion, hallucinations, severe stomach/abdominal pain, difficulty urinating, adrenal gland problems, and liver disease.
-==Interactions==
+=== Ibuprofen ===
-Hydrocodone/Ibuprofen may interact with other medications, including other opioid pain or cough relievers, alcohol, marijuana, drugs for sleep or anxiety, muscle relaxants, and antihistamines.
-==See Also==
+[[Ibuprofen]] is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme [[cyclooxygenase]] (COX), which is involved in the synthesis of [[prostaglandins]]. Prostaglandins are mediators of inflammation and pain. By reducing their production, ibuprofen decreases inflammation, pain, and fever.
-* [[Opioid]]
+== Indications ==
+Hydrocodone/ibuprofen is indicated for the short-term management of acute pain that is severe enough to require an opioid analgesic and for which alternative treatments are inadequate. It is often prescribed for conditions such as postoperative pain, injury-related pain, and severe musculoskeletal pain.
+== Dosage and Administration ==
+The dosage of hydrocodone/ibuprofen is individualized based on the patient's needs, severity of pain, and response to treatment. It is typically administered orally, with the dosage adjusted to achieve adequate pain control while minimizing adverse effects. Patients are advised to take the medication with food or milk to reduce gastrointestinal discomfort.
+== Side Effects ==
+Common side effects of hydrocodone/ibuprofen include:
+* Nausea
+* Vomiting
+* Dizziness
+* Drowsiness
+* Constipation
+Serious side effects may include:
+* Respiratory depression
+* Hepatotoxicity
+* Gastrointestinal bleeding
+* Renal impairment
+== Contraindications ==
+Hydrocodone/ibuprofen is contraindicated in patients with:
+* Known hypersensitivity to hydrocodone, ibuprofen, or any component of the formulation
+* Severe respiratory depression
+* Acute or severe bronchial asthma
+* Gastrointestinal bleeding or peptic ulcer disease
+* Severe renal or hepatic impairment
+== Related Pages ==
+* [[Opioid analgesic]]
 * [[Nonsteroidal anti-inflammatory drug]]
 * [[Pain management]]
+* [[Cyclooxygenase]]
+{{Opioids}}
+{{Analgesics}}
-[[Category:Medications]]
+[[Category:Analgesics]]
-[[Category:Pain management]]
 [[Category:Opioids]]
 [[Category:Nonsteroidal anti-inflammatory drugs]]
-{{stub}}