Artane: Difference between revisions
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{{Infobox | |||
{{Infobox drug | |||
| name = Artane | | name = Artane | ||
| | | image = <!-- Image removed --> | ||
| | | alt = | ||
| | | caption = | ||
| | | pronounce = | ||
| | | tradename = Artane | ||
| | | Drugs.com = | ||
| | | MedlinePlus = a682160 | ||
| | | pregnancy_AU = | ||
| | | pregnancy_US = C | ||
| | | legal_AU = | ||
| | | legal_CA = | ||
| | | legal_UK = | ||
| | | legal_US = Rx-only | ||
| | | routes_of_administration = Oral | ||
| | | bioavailability = | ||
| | | protein_bound = | ||
| | | metabolism = Hepatic | ||
| | | elimination_half-life = 6-10 hours | ||
| | | excretion = Renal | ||
| | | CAS_number = 52-49-3 | ||
| | | ATC_prefix = N04 | ||
| | | ATC_suffix = AA02 | ||
| | | PubChem = 5566 | ||
| | | DrugBank = DB00376 | ||
| | | ChemSpiderID = 5366 | ||
| | | UNII = 1Y1O2OM5TK | ||
| | | KEGG = D00381 | ||
| | | ChEBI = 45947 | ||
| | | ChEMBL = 1201310 | ||
| synonyms = Trihexyphenidyl | |||
}} | }} | ||
'''Artane''' | |||
== | '''Artane''' is the brand name for the drug [[Trihexyphenidyl]], which is an [[anticholinergic]] medication used primarily to treat [[Parkinson's disease]] and [[extrapyramidal symptoms]] caused by [[antipsychotic]] medications. | ||
Artane | |||
== Medical Uses == | |||
== | Artane is used to manage symptoms of [[Parkinson's disease]], such as [[tremor]], [[rigidity]], and [[bradykinesia]]. It is also effective in treating [[extrapyramidal side effects]] associated with the use of [[antipsychotic drugs]]. | ||
Artane | |||
== | == Mechanism of Action == | ||
Artane | Artane works by blocking [[acetylcholine]] receptors in the [[central nervous system]], which helps to restore the balance between [[acetylcholine]] and [[dopamine]] in the brain. This action helps to reduce the symptoms of [[Parkinson's disease]] and [[drug-induced parkinsonism]]. | ||
== | |||
Artane | == Side Effects == | ||
Common side effects of Artane include [[dry mouth]], [[blurred vision]], [[constipation]], [[urinary retention]], and [[tachycardia]]. In some cases, it may cause [[confusion]], [[hallucinations]], or [[memory impairment]], especially in older adults. | |||
== Contraindications == | |||
== | Artane is contraindicated in patients with [[narrow-angle glaucoma]], [[obstructive gastrointestinal disease]], and [[urinary retention]]. Caution is advised in patients with [[cardiovascular disease]] and [[elderly]] patients. | ||
* [[ | |||
* [[ | == Interactions == | ||
* [[ | Artane may interact with other [[anticholinergic drugs]], [[antihistamines]], and [[tricyclic antidepressants]], potentially increasing the risk of side effects. It may also interact with [[levodopa]], used in the treatment of [[Parkinson's disease]]. | ||
* [ | |||
* [ | == Dosage == | ||
* [ | The dosage of Artane is individualized based on the patient's response and tolerance. It is typically started at a low dose and gradually increased. The usual adult dose ranges from 1 mg to 15 mg per day, divided into 3 to 4 doses. | ||
== See Also == | |||
* [[Parkinson's disease]] | |||
{{ | * [[Anticholinergic]] | ||
[[Category: | * [[Extrapyramidal symptoms]] | ||
[[Category: | |||
[[Category: | == References == | ||
* [https://www.drugs.com/mtm/trihexyphenidyl.html Drugs.com: Trihexyphenidyl] | |||
* [https://www.ncbi.nlm.nih.gov/books/NBK519503/ NCBI: Trihexyphenidyl] | |||
== External Links == | |||
* [https://www.medlineplus.gov/druginfo/meds/a682160.html MedlinePlus: Trihexyphenidyl] | |||
{{Parkinson's disease treatment}} | |||
{{Anticholinergics}} | |||
[[Category:Antiparkinsonian agents]] | |||
[[Category:Anticholinergics]] | |||
[[Category:Muscarinic antagonists]] | |||
[[Category:Drugs with unknown mechanisms of action]] | |||
Latest revision as of 17:24, 27 December 2024
| Artane | |
|---|---|
| [[File:|frameless|220px|alt=|]] | |
| INN | |
| Drug class | |
| Routes of administration | Oral |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | Hepatic |
| Elimination half-life | 6-10 hours |
| Excretion | Renal |
| Legal status | |
| CAS Number | 52-49-3 |
| PubChem | 5566 |
| DrugBank | DB00376 |
| ChemSpider | 5366 |
| KEGG | D00381 |
Artane is the brand name for the drug Trihexyphenidyl, which is an anticholinergic medication used primarily to treat Parkinson's disease and extrapyramidal symptoms caused by antipsychotic medications.
Medical Uses[edit]
Artane is used to manage symptoms of Parkinson's disease, such as tremor, rigidity, and bradykinesia. It is also effective in treating extrapyramidal side effects associated with the use of antipsychotic drugs.
Mechanism of Action[edit]
Artane works by blocking acetylcholine receptors in the central nervous system, which helps to restore the balance between acetylcholine and dopamine in the brain. This action helps to reduce the symptoms of Parkinson's disease and drug-induced parkinsonism.
Side Effects[edit]
Common side effects of Artane include dry mouth, blurred vision, constipation, urinary retention, and tachycardia. In some cases, it may cause confusion, hallucinations, or memory impairment, especially in older adults.
Contraindications[edit]
Artane is contraindicated in patients with narrow-angle glaucoma, obstructive gastrointestinal disease, and urinary retention. Caution is advised in patients with cardiovascular disease and elderly patients.
Interactions[edit]
Artane may interact with other anticholinergic drugs, antihistamines, and tricyclic antidepressants, potentially increasing the risk of side effects. It may also interact with levodopa, used in the treatment of Parkinson's disease.
Dosage[edit]
The dosage of Artane is individualized based on the patient's response and tolerance. It is typically started at a low dose and gradually increased. The usual adult dose ranges from 1 mg to 15 mg per day, divided into 3 to 4 doses.
