Artane

Artane
INN
Drug class
Routes of administration	Oral
Pregnancy category
Bioavailability
Metabolism	Hepatic
Elimination half-life	6-10 hours
Excretion	Renal
Legal status
CAS Number	52-49-3
PubChem	5566
DrugBank	DB00376
ChemSpider	5366
KEGG	D00381

Artane is the brand name for the drug Trihexyphenidyl, which is an anticholinergic medication used primarily to treat Parkinson's disease and extrapyramidal symptoms caused by antipsychotic medications.

Medical Uses

Artane is used to manage symptoms of Parkinson's disease, such as tremor, rigidity, and bradykinesia. It is also effective in treating extrapyramidal side effects associated with the use of antipsychotic drugs.

Mechanism of Action

Artane works by blocking acetylcholine receptors in the central nervous system, which helps to restore the balance between acetylcholine and dopamine in the brain. This action helps to reduce the symptoms of Parkinson's disease and drug-induced parkinsonism.

Side Effects

Common side effects of Artane include dry mouth, blurred vision, constipation, urinary retention, and tachycardia. In some cases, it may cause confusion, hallucinations, or memory impairment, especially in older adults.

Contraindications

Artane is contraindicated in patients with narrow-angle glaucoma, obstructive gastrointestinal disease, and urinary retention. Caution is advised in patients with cardiovascular disease and elderly patients.

Interactions

Artane may interact with other anticholinergic drugs, antihistamines, and tricyclic antidepressants, potentially increasing the risk of side effects. It may also interact with levodopa, used in the treatment of Parkinson's disease.

Dosage

The dosage of Artane is individualized based on the patient's response and tolerance. It is typically started at a low dose and gradually increased. The usual adult dose ranges from 1 mg to 15 mg per day, divided into 3 to 4 doses.

See Also

• Parkinson's disease
• Anticholinergic
• Extrapyramidal symptoms

References

• Drugs.com: Trihexyphenidyl
• NCBI: Trihexyphenidyl

External Links

• MedlinePlus: Trihexyphenidyl