Rapacuronium bromide
Rapacuronium bromide
Rapacuronium bromide (pronunciation: ra-pa-cu-ro-ni-um bro-mide) is a non-depolarizing neuromuscular-blocking drug or muscle relaxant used in modern anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Etymology
The term "Rapacuronium" is derived from the Latin word 'rapax', meaning 'ravenous' or 'greedy', and 'curare', a term for various plant extract alkaloid arrow poisons used by the indigenous peoples of South America. The suffix '-onium' is a standard ending for all quaternary ammonium muscle relaxants. 'Bromide' refers to the bromide salt form of the drug.
Pharmacology
Rapacuronium bromide acts by competitively binding to nicotinic acetylcholine receptors on the motor end-plate. This antagonizes the action of acetylcholine, resulting in flaccid muscle paralysis.
Related Terms
- Neuromuscular-blocking drug
- Muscle relaxant
- Anesthesia
- Endotracheal intubation
- Nicotinic acetylcholine receptors
- Acetylcholine
Side Effects
Common side effects of rapacuronium bromide include hypotension, tachycardia, and bronchospasm. Due to its potential to cause severe bronchospasm, the drug was withdrawn from the market in 2001.
See Also
External links
- Medical encyclopedia article on Rapacuronium bromide
- Wikipedia's article - Rapacuronium bromide
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