Bioavailability
Bioavailability
Bioavailability (/ˌbaɪ.oʊ.əˈveɪ.ləˌbɪl.ɪ.ti/) is a term used in pharmacology and nutritional science to refer to the extent and rate at which an administered drug or other substance becomes available to the body's circulatory system. The term is derived from the Greek words "bios" meaning life and "avail" meaning to have or hold.
Definition
Bioavailability is a measurement of the rate and extent to which a drug reaches at the site of action. It is a crucial measurement in drug design and drug development. The concept of bioavailability is used in pharmacokinetics and pharmacodynamics.
Factors affecting Bioavailability
Several factors can affect the bioavailability of a drug or substance. These include the drug's physical and chemical properties, its formulation and route of administration, the patient's physiological condition, and the presence of other substances.
Measurement
Bioavailability is typically measured by calculating the area under the plasma concentration-time curve (AUC). This measurement is often used in pharmacokinetic studies.
Related Terms
- Pharmacokinetics: The study of how the body affects a specific drug after administration.
- Pharmacodynamics: The study of the biochemical and physiological effects of drugs on the body.
- Plasma: The liquid component of blood, in which the blood cells are suspended.
See Also
External links
- Medical encyclopedia article on Bioavailability
- Wikipedia's article - Bioavailability
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