Coronaridine

Coronaridine is an alkaloid that is naturally found in a variety of plants, including those in the Apocynaceae family. It is a member of the iboga alkaloid group, which is known for its psychoactive properties. Coronaridine itself, however, is not psychoactive.

Chemical Structure and Properties

Coronaridine is a terpenoid indole alkaloid. Its chemical formula is C22H26N2O3, and it has a molecular weight of 366.45 g/mol. The compound is structurally similar to other iboga alkaloids, such as ibogaine and voacangine, but it lacks their psychoactive properties.

Natural Occurrence

Coronaridine is found in a variety of plants, most notably those in the Apocynaceae family. This includes the Tabernanthe iboga plant, which is native to Central Africa and is known for its use in traditional medicine and spiritual practices. Other plants that contain coronaridine include Voacanga africana and Tabernaemontana undulata.

Biological Activity

While coronaridine is not psychoactive, it does have biological activity. It has been found to have anti-inflammatory and analgesic properties, and it may also have potential as an anti-cancer agent. Research is ongoing to further understand the potential medical applications of coronaridine.

Synthesis

Coronaridine can be synthesized from voacangine, another iboga alkaloid. The process involves a series of chemical reactions, including reduction and acetylation.

See Also

• Ibogaine
• Voacangine
• Tabernanthe iboga
• Voacanga africana
• Tabernaemontana undulata

References

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  Coronaridine structure diagram

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  Coronaridine ball-and-stick model