ABT-894

ABT-894
[[File:|frameless|220px|alt=|Chemical structure of ABT-894]]
INN
Drug class
Routes of administration	Oral
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status	Investigational
CAS Number	851333-14-5
PubChem	11524336
DrugBank
ChemSpider	9700483
KEGG

ABT-894 is a pharmaceutical drug that was developed as a selective agonist for the nicotinic acetylcholine receptor (nAChR), specifically targeting the α4β2 subtype. It was investigated for its potential therapeutic effects in treating attention deficit hyperactivity disorder (ADHD) and neuropathic pain.

Mechanism of Action

ABT-894 functions by selectively binding to and activating the α4β2 nicotinic acetylcholine receptors in the central nervous system. These receptors are involved in modulating neurotransmitter release and are implicated in cognitive processes such as attention and memory. By enhancing the activity of these receptors, ABT-894 was hypothesized to improve cognitive function and reduce symptoms of ADHD.

Clinical Development

ABT-894 underwent several clinical trials to evaluate its efficacy and safety. Early studies suggested that it might have beneficial effects in improving attention and reducing hyperactivity in patients with ADHD. However, the development of ABT-894 was eventually discontinued, and it did not reach the market.

Potential Applications

While ABT-894 was primarily investigated for ADHD, its mechanism of action suggested potential applications in other conditions involving cognitive dysfunction or neuropathic pain. The α4β2 nAChR is a target of interest in various neurological disorders, and compounds like ABT-894 continue to be of scientific interest.

Research and Development

The development of ABT-894 was part of a broader effort to explore nicotinic acetylcholine receptor agonists as therapeutic agents. Research in this area continues, with ongoing studies exploring the role of nAChR in various diseases and the potential for new drugs targeting these receptors.

See Also

• Nicotinic acetylcholine receptor
• Attention deficit hyperactivity disorder
• Neuropathic pain
• Pharmaceutical drug development

References

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