SSR-180,711

SSR-180,711‏‎ is a drug that acts as a potent and selective antagonist for the Alpha-7 nicotinic acetylcholine receptor. It has been researched for its potential therapeutic applications in the treatment of schizophrenia, cognitive deficits, and Alzheimer's disease.

Pharmacology

SSR-180,711‏‎ is a selective antagonist for the Alpha-7 nicotinic acetylcholine receptor. This receptor is a type of nicotinic acetylcholine receptor, which is a class of ionotropic receptors that respond to the neurotransmitter acetylcholine. The Alpha-7 receptor subtype is found in the brain and is thought to play a role in cognitive functions such as learning and memory.

Therapeutic Potential

SSR-180,711‏‎ has been investigated for its potential use in the treatment of several neurological and psychiatric disorders.

Schizophrenia

In preclinical studies, SSR-180,711‏‎ has shown promise as a potential treatment for schizophrenia. The drug appears to improve cognitive deficits associated with the disorder, which are not effectively treated by current antipsychotic medications.

Alzheimer's Disease

SSR-180,711‏‎ may also have potential in the treatment of Alzheimer's disease. The Alpha-7 nicotinic receptor is thought to play a role in the pathophysiology of Alzheimer's, and SSR-180,711‏‎'s ability to antagonize this receptor could potentially slow the progression of the disease.

References

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SSR-180,711 chemical structure

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