Aceclidine
A parasympathomimetic agent used in ophthalmology
| Aceclidine | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | Topical (eye drops) |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | Rx-only |
| CAS Number | 827-61-2 |
| PubChem | 1987 |
| DrugBank | DB13532 |
| ChemSpider | 1911 |
| KEGG | D02747 |
Aceclidine is a parasympathomimetic agent that is primarily used in the field of ophthalmology to treat glaucoma. It functions as a muscarinic acetylcholine receptor agonist, which leads to the contraction of the ciliary muscle and the sphincter muscle of the iris, resulting in miosis and a decrease in intraocular pressure.
Pharmacology[edit]
Aceclidine is a cholinergic drug that mimics the action of the neurotransmitter acetylcholine. It specifically targets the muscarinic receptors in the eye, leading to increased outflow of aqueous humor and reduced intraocular pressure. This makes it effective in the management of open-angle glaucoma and ocular hypertension.
Mechanism of Action[edit]
Aceclidine acts by stimulating the muscarinic receptors in the eye, which are part of the parasympathetic nervous system. This stimulation causes the ciliary muscle to contract, opening the trabecular meshwork and facilitating the drainage of aqueous humor from the anterior chamber of the eye. The contraction of the sphincter muscle of the iris also results in miosis, which can help in reducing intraocular pressure.
Clinical Use[edit]
Aceclidine is administered as eye drops for the treatment of glaucoma and ocular hypertension. It is particularly useful in patients who are intolerant to other antiglaucoma medications or in combination with other drugs to achieve better control of intraocular pressure.
Side Effects[edit]
Common side effects of aceclidine include eye irritation, blurred vision, and headache. Due to its action on the parasympathetic nervous system, it may also cause systemic effects such as sweating, salivation, and nausea if absorbed in significant amounts.
Related pages[edit]
Gallery[edit]
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Chemical structure of Aceclidine -
3D ball-and-stick model of Aceclidine
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Aceclidine.svg
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Aceclidine 3D ball
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