Piroheptine

An anticholinergic drug used in the treatment of Parkinson's disease

Piroheptine
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Piroheptine is a pharmacological agent classified as an anticholinergic drug. It is primarily used in the management of Parkinson's disease, a neurodegenerative disorder characterized by tremor, rigidity, and bradykinesia.

Mechanism of Action

Piroheptine functions by inhibiting the action of acetylcholine, a neurotransmitter involved in the regulation of motor control. By blocking acetylcholine receptors, piroheptine helps to restore the balance between acetylcholine and dopamine in the central nervous system, which is often disrupted in Parkinson's disease.

Pharmacokinetics

Piroheptine is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily through the renal system. The drug has a moderate half-life, allowing for dosing multiple times a day to maintain therapeutic levels.

Clinical Use

Piroheptine is indicated for the treatment of Parkinsonian syndromes, including idiopathic Parkinson's disease and drug-induced parkinsonism. It is often used in combination with other antiparkinsonian agents such as levodopa to enhance therapeutic outcomes.

Side Effects

Common side effects of piroheptine include dry mouth, constipation, urinary retention, and blurred vision. These effects are typical of anticholinergic drugs due to their action on the parasympathetic nervous system.

Contraindications

Piroheptine is contraindicated in patients with glaucoma, prostatic hypertrophy, and obstructive gastrointestinal disorders. Caution is advised in elderly patients due to the increased risk of cognitive impairment.

Related pages

• Parkinson's disease
• Anticholinergic
• Neurotransmitter
• Dopamine

• 

  Piroheptine