Phosphodiesterase inhibitor

Phosphodiesterase inhibitor

A Phosphodiesterase inhibitor (pronunciation: /ˌfɒsfəˈdaɪɛstəreɪz ɪnˈhɪbɪtər/) is a type of drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). The ubiquity of the enzyme type means that non-specific inhibitors have a wide range of actions and can produce a variety of side effects.

Etymology

The term "Phosphodiesterase inhibitor" is derived from the enzyme it inhibits, "Phosphodiesterase", and the term "inhibitor" which refers to a substance that slows down or stops a chemical reaction.

Types of Phosphodiesterase inhibitors

There are several types of Phosphodiesterase inhibitors, each with their own specific uses and effects. These include:

• PDE5 inhibitors, used to treat conditions like erectile dysfunction and pulmonary hypertension.
• PDE4 inhibitors, used to treat inflammatory diseases such as asthma, COPD, and psoriasis.
• PDE3 inhibitors, used to treat conditions like heart failure and cardiogenic shock.

Related terms

• Enzyme inhibitor
• Cyclic nucleotide phosphodiesterases
• Second messenger system
• Cyclic AMP
• Cyclic GMP

External links

• Medical encyclopedia article on Phosphodiesterase inhibitor
• Wikipedia's article - Phosphodiesterase inhibitor

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