Prostaglandin E2

Prostaglandin E2

Prostaglandin E2 (PGE2) is a bioactive lipid that plays a crucial role in various physiological and pathological processes. It is one of the most abundant and biologically active prostaglandins in the human body.

Pronunciation

Prostaglandin E2 is pronounced as "pros-tuh-GLAN-din E2".

Etymology

The term "prostaglandin" derives from the prostate gland, where the compound was first isolated by Swedish biochemist Sune Bergström in the 1930s. The "E2" refers to the specific structural form of the prostaglandin molecule.

Function

PGE2 is produced by almost all cell types and has diverse biological activities. It is involved in the regulation of inflammation, fever, pain perception, and blood pressure. It also plays a role in immune response, gastrointestinal integrity, and reproductive functions.

Synthesis

PGE2 is synthesized from arachidonic acid through the action of cyclooxygenase enzymes (COX-1 and COX-2) and specific prostaglandin E synthases.

Related Terms

• Arachidonic acid
• Cyclooxygenase
• Inflammation
• Prostaglandin
• Sune Bergström

See Also

• Prostaglandin D2
• Prostaglandin F2 alpha
• Prostaglandin I2

External links

• Medical encyclopedia article on Prostaglandin E2
• Wikipedia's article - Prostaglandin E2

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