Prostaglandin F receptor

Prostaglandin F receptor (also known as FP) is a protein that in humans is encoded by the PTGFR gene. It is a member of the G protein-coupled receptor family and plays a significant role in various physiological and pathological processes.

Function

The Prostaglandin F receptor is a cell surface receptor that is predominantly expressed in the uterus, lung, and eye. It is involved in the regulation of many biological processes, including inflammation, immune response, and contraction of smooth muscle. The receptor is activated by binding to its ligand, prostaglandin F2alpha (PGF2α), which triggers a cascade of intracellular events leading to the physiological response.

Clinical significance

Alterations in the function of the Prostaglandin F receptor have been implicated in a variety of diseases. For example, mutations in the PTGFR gene have been associated with primary congenital glaucoma, a rare eye disorder. In addition, overexpression of the receptor has been observed in certain types of cancer, suggesting a potential role in tumorigenesis.

Pharmacology

Several drugs have been developed to target the Prostaglandin F receptor. These include latanoprost, a PGF2α analogue used in the treatment of glaucoma, and carboprost, a synthetic prostaglandin used to induce labor or cause an abortion.

See also

• Prostaglandin receptors
• G protein-coupled receptor
• Prostaglandin F2alpha

References

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