Grapiprant
Grapiprant (pronounced gra-PIP-rant) is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine to treat osteoarthritis in dogs. It is marketed under the brand name Galliprant.
Etymology
The term "Grapiprant" is a coined name, with no specific etymology. It is a proprietary name for a specific NSAID used in veterinary medicine.
Pharmacology
Grapiprant is a selective antagonist of the prostaglandin E2 (PGE2) EP4 receptor. The EP4 receptor is the primary mediator of inflammatory pain and fever. By blocking this receptor, Grapiprant reduces pain and inflammation associated with osteoarthritis in dogs.
Usage
Grapiprant is used to control pain and inflammation associated with osteoarthritis in dogs. It is administered orally once a day. The drug is available in tablet form in various strengths to accommodate different sizes and weights of dogs.
Side Effects
Possible side effects of Grapiprant include vomiting, diarrhea, decreased appetite, and lethargy. In rare cases, it may cause abnormal liver function tests, low protein in the blood, and kidney dysfunction.
Related Terms
- Nonsteroidal anti-inflammatory drug (NSAID): A class of drugs that provides analgesic and antipyretic effects, and, in higher doses, anti-inflammatory effects.
- Osteoarthritis: A type of arthritis that occurs when flexible tissue at the ends of bones wears down.
- Prostaglandin E2 (PGE2): One of the prostaglandins, which are a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body.
- EP4 receptor: A protein that is encoded by the PTGER4 gene in humans.
External links
- Medical encyclopedia article on Grapiprant
- Wikipedia's article - Grapiprant
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