Aceclofenac

Aceclofenac

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It operates by inhibiting the action of a substance in the body called cyclooxygenase (COX), which is involved in the production of prostaglandins, substances that cause pain, swelling, and inflammation.

Pharmacology

Aceclofenac works by inhibiting the enzyme cyclooxygenase, which is involved in the synthesis of prostaglandins. There are two isoforms of cyclooxygenase: COX-1 and COX-2. Aceclofenac, like other NSAIDs, primarily inhibits COX-2, the isoform of the enzyme involved in the production of inflammatory prostaglandins. Inhibition of COX-2 by aceclofenac reduces the production of prostaglandins, leading to reduced inflammation and pain.

Indications

Aceclofenac is indicated for the relief of pain and inflammation associated with Rheumatoid arthritis, Osteoarthritis, and Ankylosing spondylitis. It is also used in the treatment of other musculoskeletal and joint disorders, as well as for the alleviation of post-operative pain.

Side Effects

The use of aceclofenac, as with other NSAIDs, can be associated with a range of adverse effects. The most common side effects include gastrointestinal issues such as nausea, dyspepsia, abdominal pain, and diarrhea. It can also cause dizziness, headache, and skin rashes. More serious but less common side effects include gastrointestinal bleeding, ulceration, hypertension, heart failure, renal impairment, and hypersensitivity reactions.

Contraindications

Aceclofenac is contraindicated in patients with hypersensitivity to the drug, those with active or history of recurrent peptic ulcer/haemorrhage, and in patients with severe heart failure, hepatic failure, or renal failure. It should also be used with caution in patients with a history of gastrointestinal disease and those taking anticoagulant therapy.

Dosage and Administration

The typical dosage of aceclofenac is 100 mg twice daily, taken orally, preferably with food to minimize gastrointestinal discomfort. The dose may be adjusted based on the severity of the condition and the patient's response to treatment.

Comparison with Other NSAIDs

Aceclofenac is similar in efficacy and safety profile to other NSAIDs, such as Ibuprofen and Diclofenac. However, it is often preferred for its better gastrointestinal tolerability and lower incidence of cardiovascular risks compared to some other NSAIDs.

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