Mofezolac
Mofezolac is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of pain and inflammation associated with conditions such as arthritis. It works by inhibiting the production of prostaglandins, substances in the body that cause inflammation and pain.
Pharmacology
Mofezolac selectively inhibits the enzyme cyclooxygenase-1 (COX-1), which is responsible for the production of prostaglandins. This results in decreased production of these substances, leading to reduced inflammation and pain. Unlike other NSAIDs, mofezolac does not inhibit cyclooxygenase-2 (COX-2), an enzyme that is also involved in the inflammatory response but is not associated with the side effects seen with non-selective NSAIDs.
Clinical Use
Mofezolac is used in the treatment of pain and inflammation associated with various conditions, including arthritis. It is also used for the relief of acute pain, such as that associated with surgery or dental procedures.
Side Effects
As with other NSAIDs, mofezolac can cause a variety of side effects. These can include gastrointestinal problems such as stomach ulcers and bleeding, as well as kidney problems. It can also cause allergic reactions in some people.
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Contributors: Prab R. Tumpati, MD
