Proglumetacin

Proglumetacin

Proglumetacin (pronunciation: pro-glu-me-ta-cin) is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of pain and inflammation in conditions such as arthritis. It is also known by the brand name Protizinic.

Etymology

The term "Proglumetacin" is derived from the names of its two active metabolites, probenecid and glucose metabolite of cinchophen.

Pharmacology

Proglumetacin is a prodrug, which means it is metabolized in the body to produce its active forms, probenecid and a glucose metabolite of cinchophen. These metabolites exert their effects by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are involved in the production of prostaglandins, substances that cause inflammation and pain.

Usage

Proglumetacin is used to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is also used to treat acute gout attacks.

Side Effects

Like other NSAIDs, Proglumetacin can cause side effects such as stomach upset, nausea, vomiting, headache, dizziness, and rash. More serious side effects can include stomach or intestinal bleeding, kidney damage, and heart problems.

Related Terms

• Non-steroidal anti-inflammatory drug
• Pain
• Inflammation
• Arthritis
• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Gout
• Probenecid
• Cinchophen
• Cyclooxygenase
• Prostaglandins

External links

• Medical encyclopedia article on Proglumetacin
• Wikipedia's article - Proglumetacin

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