Prostaglandin E2 receptor
Prostaglandin E2 receptor (often abbreviated as EP) is a G protein-coupled receptor that binds to the prostaglandin E2 (PGE2). The receptor is part of the Eicosanoid receptor group, which includes four different subtypes: EP1, EP2, EP3, and EP4. Each subtype has a unique biological function and distribution in the body.
Function
The primary function of the Prostaglandin E2 receptor is to mediate the effects of PGE2, which is a lipid compound derived from fatty acids and involved in inflammation and fever. PGE2 itself is a potent vasodilator and immunomodulator, and its effects are mediated through its binding to the EP receptors.
Subtypes
EP1
The EP1 receptor subtype is primarily involved in the regulation of blood pressure and gastric acid secretion. It is found in various tissues, including the kidney, stomach, and central nervous system.
EP2
The EP2 receptor subtype is involved in the regulation of immune response, vasodilation, and bronchodilation. It is found in various tissues, including the lung, spleen, and thymus.
EP3
The EP3 receptor subtype has a complex role in the regulation of body temperature, pain perception, and uterine contractions. It is found in various tissues, including the brain, uterus, and gastrointestinal tract.
EP4
The EP4 receptor subtype is involved in the regulation of inflammation, bone metabolism, and tumor growth. It is found in various tissues, including the bone, colon, and prostate.
Clinical significance
The Prostaglandin E2 receptor and its subtypes have been implicated in various diseases, including cancer, rheumatoid arthritis, and asthma. As such, they are potential targets for drug therapy.
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