Ro01-6128

Ro01-6128 is a pharmacological compound that belongs to the class of benzodiazepine drugs. It is a psychoactive drug that possesses anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.

Pharmacology

Ro01-6128 is a benzodiazepine receptor agonist. It binds to the GABA (gamma-aminobutyric acid) receptors in the brain, enhancing the effects of this inhibitory neurotransmitter and leading to sedative and anxiolytic effects.

Medical Uses

Ro01-6128 is primarily used for the treatment of anxiety disorders, insomnia, seizures, and muscle spasms. It is also used as a premedication for medical or dental procedures to induce sedation and amnesia.

Side Effects

Common side effects of Ro01-6128 include drowsiness, dizziness, and impaired coordination. Long-term use can lead to physical dependence and withdrawal symptoms upon discontinuation.

History

Ro01-6128 was first synthesized in the 1970s by Roche, a Swiss multinational healthcare company. It is part of the larger family of benzodiazepine drugs, which were first discovered in the 1950s.

Benzodiazipines

Anticonvulsants Drugs

Anticonvulsants, and Benzodiazepines]

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Sedatives and Hypnotics

Barbiturates

Benzodiazepines
- Diazepam
- Estazolam
- Flurazepam
- Quazepam
- Temazepam
- Triazolam

Benzodiazepine Receptor Agonists

Herbals
- Chamomile (Matricaria recutita)
- Hops (Humulus lupulus)
- Lavender (Lavandula angustifolia)
- Passionflower (Passiflora incarnata)
- Valerian (Valeriana officinalis)

Melatonin and its Analogues

Miscellaneous Agents

- Buspirone
- Chloral hydrate
- Doxepin
- Meprobamate
- Sodium Oxybate (Narcolepsy Agent)
- Suvorexant

Muscle relaxants

Ro01-6128

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