Ro01-6128: Difference between revisions

Ro01-6128 is a pharmacological compound that belongs to the class of benzodiazepine drugs. It is a psychoactive drug that possesses anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.

Pharmacology[edit]

Ro01-6128 is a benzodiazepine receptor agonist. It binds to the GABA (gamma-aminobutyric acid) receptors in the brain, enhancing the effects of this inhibitory neurotransmitter and leading to sedative and anxiolytic effects.

Medical Uses[edit]

Ro01-6128 is primarily used for the treatment of anxiety disorders, insomnia, seizures, and muscle spasms. It is also used as a premedication for medical or dental procedures to induce sedation and amnesia.

Side Effects[edit]

Common side effects of Ro01-6128 include drowsiness, dizziness, and impaired coordination. Long-term use can lead to physical dependence and withdrawal symptoms upon discontinuation.

History[edit]

Ro01-6128 was first synthesized in the 1970s by Roche, a Swiss multinational healthcare company. It is part of the larger family of benzodiazepine drugs, which were first discovered in the 1950s.

Benzodiazipines[edit]

Anticonvulsants Drugs[edit]

Anticonvulsants, and Benzodiazepines]

Psychoactive drugs

Stimulants	* Amphetamine Caffeine Cocaine Methamphetamine
Depressants	* Alcohol Barbiturate Benzodiazepine GHB Opiate Opioid
Hallucinogens	* LSD Psilocybin MDMA Mescaline DMT
Cannabis	* Cannabis Hashish Medical cannabis
Dissociatives	* Ketamine PCP Nitrous oxide DXM

This psychoactive drug related article is a stub.

v t e Anxiolytics (N05B)
5-HT_1AR agonists	Buspirone Gepirone Tandospirone
GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Carisoprodol Chlormezanone^‡ Ethanol (alcohol) Etifoxine
Hypnotics	Zopiclone
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs (e.g., escitalopram) SNRIs (e.g., duloxetine) SARIs (e.g., trazodone) TCAs (e.g., clomipramine^#) TeCAs (e.g., mirtazapine) MAOIs (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Antipsychotics	Quetiapine Flupentixol
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cycloserine Fabomotizole Hydroxyzine Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Anticonvulsants (N03)

GABAergics

GABA_AR PAMs	* Barbiturates: Barbexaclone Metharbital Methylphenobarbital Pentobarbital Phenobarbital^# Primidone; Carbamates: Cenobamate Felbamate; Benzodiazepines: Clobazam Clonazepam Clorazepate Diazepam^# Lorazepam^# Midazolam Nimetazepam Nitrazepam Temazepam; Others: Bromide (potassium bromide, sodium bromide) Imepitoin Paraldehyde Stiripentol
GABA-T inhibitors	* Fatty acids (and related): Valproate Valpromide Valproate pivoxil Vigabatrin
Others	* GABAR agonists: Progabide; GAT-1 inhibitors: Tiagabine

Channel
modulators

Sodium blockers	* Hydantoins: Ethotoin Fosphenytoin Mephenytoin Phenytoin^#; Ureides: Acetylpheneturide Chlorphenacemide Phenacemide^‡ Pheneturide; Fatty acids: Valproate Valpromide Valproate pivoxil; Carboxamides: Carbamazepine^# Eslicarbazepine acetate Oxcarbazepine; Others: Lacosamide Lamotrigine^# Rufinamide Topiramate Zonisamide
Calcium blockers	* Oxazolidinediones: Ethadione Paramethadione Trimethadione; Succinimides: Ethosuximide^# Mesuximide Phensuximide; Gabapentinoids: Gabapentin Pregabalin; Others: Imepitoin Lamotrigine^# Topiramate Zonisamide
Potassium openers	* Retigabine

Others

CA inhibitors	* Sulfonamides: Acetazolamide Ethoxzolamide Sultiame Topiramate Zonisamide
Others	* Albutoin Beclamide Brivaracetam Cannabidiol Carisbamate Etiracetam Fenfluramine Ganaxolone Levetiracetam Perampanel

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Hypnotics and Sedatives
ATC Code: N05C

GABA_A

- 2M2B - Chloralodol - Ethanol (alcohol) - Diethylpropanediol - Ethchlorvynol - Methylpentynol - Trichloroethanol Barbiturates - Allobarbital - Amobarbital - Aprobarbital - Barbital - Butabarbital - Butobarbital - Cyclobarbital - Ethallobarbital - Heptabarb - Hexobarbital - Mephobarbital - Methohexital - Narcobarbital - Pentobarbital - Phenallymal - Phenobarbital - Propylbarbital - Proxibarbal - Reposal - Secobarbital - Talbutal - Thiamylal - Thiopental - Thiotetrabarbital - Vinbarbital - Vinylbital

Benzodiazepines - Brotizolam - Cinolazepam - Climazolam - Clonazolam - Doxefazepam - Estazolam - Flubromazolam - Flunitrazolam - Flunitrazepam - Flurazepam - Flutemazepam - Flutoprazepam - Loprazolam - Lormetazepam - Midazolam - Nimetazepam - Nitemazepam - Nitrazepam - Nitrazolam - Quazepam - Temazepam - Triazolam

Carbamates - Carisoprodol - Emylcamate - Meprobamate - Methocarbamol Imidazoles - Etomidate - Metomidate - Propoxate Monoureides - Acecarbromal - Apronal (apronalide) - Bromisoval - Capuride - Carbromal - Ectylurea Neuroactive Steroids - Acebrochol - Allopregnanolone - Alphadolone - Alphaxolone - Eltanolone - Hydroxydione - Minaxolone - Progesterone Nonbenzodiazepines - Eszopiclone - Indiplon - Lirequinil - Necopidem - Pazinaclone - Saripidem - Suproclone - Suriclone - Zaleplon - Zolpidem - Zopiclone Phenols - Propofol Piperidinediones - Glutethimide - Methyprylon - Pyrithyldione - Piperidione Quinazolinones - Afloqualone - Cloroqualone - Diproqualone - Etaqualone - Mebroqualone - Mecloqualone - Methaqualone - Methylmethaqualone - Nitromethaqualone - SL-164 Others - Acetophenone - Chloral hydrate - Chloralose - Clomethiazole - Dichloralphenazone - Gaboxadol - Kavalactones - Loreclezole - Paraldehyde - Petrichloral - Sulfonmethane

Sedatives and Hypnotics[edit]

Barbiturates

Benzodiazepines
- Diazepam
- Estazolam
- Flurazepam
- Quazepam
- Temazepam
- Triazolam

Benzodiazepine Receptor Agonists

Herbals
- Chamomile (Matricaria recutita)
- Hops (Humulus lupulus)
- Lavender (Lavandula angustifolia)
- Passionflower (Passiflora incarnata)
- Valerian (Valeriana officinalis)

Melatonin and its Analogues

Miscellaneous Agents

- Buspirone
- Chloral hydrate
- Doxepin
- Meprobamate
- Sodium Oxybate (Narcolepsy Agent)
- Suvorexant

Muscle relaxants

Amnestics in WikiMD

Types	* Class A Amnestic Class B Amnestic Class C Amnestic Class D Amnestic Class E Amnestic Class F Amnestic
Usage	* Administration Methods Ethical Considerations Historical Use of Amnestics Amnestic Syndrome
Related Topics	* Memory Erasure Cognitive Rehabilitation Neuroethics Psychopharmacology
Research and Development	* Amnestic Research Programs Future of Amnestics Neuroscience of Memory

This Amnestics related article is a stub.

Ro01-6128

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 {{Muscle relaxants}}
 {{Amnestics}}
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Latest revision as of 01:11, 20 February 2025