Testifenon

Testifenon
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number	104730-58-7
PubChem	128659
DrugBank
ChemSpider	114020
KEGG

Testifenon, also known as testiphenon, testiphenone, chlorphenacyl dihydrotestosterone ester, or dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic anabolic–androgenic steroid (AAS) and a cytostatic antineoplastic agent (i.e., chemotherapeutic) that was never marketed.<ref name="pmid3201773">,

 [The antineoplastic activity of testiphenon], 
 Vopr Onkol, 
 1988,
 Vol. 34(Issue: 11),
 pp. 1363–8,
 
 PMID: 3201773,</ref><ref name="DemidovaSerebryakova1995">, 
 Comparative pharmacokinetics of3H-testiphenone and3H-chlorophenacyl in peroral administration to mice, 
 Pharmaceutical Chemistry Journal, 
 1995,
 Vol. 29(Issue: 11),
 pp. 737–739,
 DOI: 10.1007/BF02331848,</ref><ref name="pmid11882971">, 
 [Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics], 
 Vestn. Akad. Med. Nauk SSSR, 
 2002,
 
 pp. 42–5,
 
 PMID: 11882971,</ref> It is an androgen ester – specifically, a chlorphenacyl nitrogen mustard ester of dihydrotestosterone (DHT) – and acts as a prodrug of these two components in the body.<ref name="pmid3201773" /><ref name="DemidovaSerebryakova1995" /> The drug was developed in Russia as a tissue-selective cytostatic drug for the treatment of various cancers occurring in androgen receptor-expressing tissues that would have reduced side effects and toxicity relative to other chemotherapy drugs.<ref name="pmid3201773" /><ref name="DemidovaSerebryakova1995" />

See also

• List of hormonal cytostatic antineoplastic agents
• List of androgen esters § Dihydrotestosterone esters