Testifenon: Difference between revisions
From WikiMD's Wellness Encyclopedia
CSV import |
CSV import |
||
| Line 82: | Line 82: | ||
{{Antineoplastic-drug-stub}} | {{Antineoplastic-drug-stub}} | ||
{{dictionary-stub1}} | {{dictionary-stub1}} | ||
<gallery> | |||
File:Testifenon.svg|Diagram of Testifenon | |||
File:Testifenon_molecule_ball.png|Ball-and-stick model of Testifenon | |||
</gallery> | |||
Revision as of 02:00, 17 February 2025
| Testifenon | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | 104730-58-7 |
| PubChem | 128659 |
| DrugBank | |
| ChemSpider | 114020 |
| KEGG | |
Testifenon, also known as testiphenon, testiphenone, chlorphenacyl dihydrotestosterone ester, or dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic anabolic–androgenic steroid (AAS) and a cytostatic antineoplastic agent (i.e., chemotherapeutic) that was never marketed.<ref name="pmid3201773">,
[The antineoplastic activity of testiphenon], Vopr Onkol, 1988, Vol. 34(Issue: 11), pp. 1363–8, PMID: 3201773,</ref><ref name="DemidovaSerebryakova1995">, Comparative pharmacokinetics of3H-testiphenone and3H-chlorophenacyl in peroral administration to mice, Pharmaceutical Chemistry Journal, 1995, Vol. 29(Issue: 11), pp. 737–739, DOI: 10.1007/BF02331848,</ref><ref name="pmid11882971">, [Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics], Vestn. Akad. Med. Nauk SSSR, 2002, pp. 42–5, PMID: 11882971,</ref> It is an androgen ester – specifically, a chlorphenacyl nitrogen mustard ester of dihydrotestosterone (DHT) – and acts as a prodrug of these two components in the body.<ref name="pmid3201773" /><ref name="DemidovaSerebryakova1995" /> The drug was developed in Russia as a tissue-selective cytostatic drug for the treatment of various cancers occurring in androgen receptor-expressing tissues that would have reduced side effects and toxicity relative to other chemotherapy drugs.<ref name="pmid3201773" /><ref name="DemidovaSerebryakova1995" />
See also
- List of hormonal cytostatic antineoplastic agents
- List of androgen esters § Dihydrotestosterone esters
References
<references group="" responsive="1"></references>
