Liposomal amphotericin B

Liposomal amphotericin B

Liposomal amphotericin B (pronunciation: li-PO-so-mal am-foe-TER-i-sin B) is a type of antifungal medication used to treat a variety of serious fungal infections. It is a form of the drug amphotericin B that has been encapsulated within a liposome.

Etymology

The term "liposomal" is derived from "liposome", a type of tiny bubble made out of the same material as a cell membrane. "Amphotericin B" is named for its broad-spectrum antifungal activity, with "amphi-" meaning "both kinds" in Greek, and "-tericin" indicating its role as an antibiotic.

Usage

Liposomal amphotericin B is used to treat severe fungal infections such as cryptococcal meningitis, histoplasmosis, and aspergillosis. It is also used to treat parasitic infections such as visceral leishmaniasis.

Mechanism of Action

Liposomal amphotericin B works by binding to ergosterol, a component of fungal cell membranes, creating pores that disrupt the membrane and lead to cell death. The liposomal formulation allows for targeted delivery of the drug, reducing toxicity and improving efficacy.

Side Effects

Common side effects of liposomal amphotericin B include fever, chills, headache, and nausea. More serious side effects can include kidney damage, low potassium levels, and anemia.

Related Terms

• Amphotericin B deoxycholate
• Liposomal drug delivery
• Antifungal drug
• Invasive fungal infection

See Also

• List of antifungal medications
• List of liposomal drugs

External links

• Medical encyclopedia article on Liposomal amphotericin B
• Wikipedia's article - Liposomal amphotericin B

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