Pyrimidine analogue
Pyrimidine Analogue
Pyrimidine analogue (pronunciation: /pɪˈrɪmɪdiːn ˈænəlɒɡ/) is a type of antimetabolite used in chemotherapy and antiviral therapy.
Etymology
The term "pyrimidine analogue" is derived from the word "pyrimidine", which is a type of nitrogenous base found in DNA and RNA, and "analogue", which refers to a compound with a structure similar to that of another compound.
Definition
A pyrimidine analogue is a chemical compound that is structurally similar to a naturally occurring pyrimidine. These analogues can interfere with the synthesis and function of nucleic acids in a cell, making them useful in the treatment of certain diseases.
Usage
Pyrimidine analogues are used in the treatment of various types of cancer and viral infections. They work by inhibiting the synthesis of DNA or RNA, thereby preventing the replication of cancer cells or viruses.
Examples
Examples of pyrimidine analogues include 5-fluorouracil, cytarabine, and gemcitabine, which are used in chemotherapy, and lamivudine and zidovudine, which are used in antiviral therapy.
Related Terms
- Antimetabolite
- Chemotherapy
- Antiviral therapy
- Nucleic acids
- Cancer
- 5-fluorouracil
- Cytarabine
- Gemcitabine
- Lamivudine
- Zidovudine
External links
- Medical encyclopedia article on Pyrimidine analogue
- Wikipedia's article - Pyrimidine analogue
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