Echinocandin
Echinocandin
Echinocandin (pronunciation: eh-kee-no-can-din) is a class of antifungal drugs that inhibit the synthesis of beta-glucan, a component of the fungal cell wall.
Etymology
The term "echinocandin" is derived from the name of the fungus Echinocandin, from which the first drug of this class was isolated. The suffix "-candin" is used for drugs that inhibit the synthesis of fungal cell wall components.
Related Terms
Usage
Echinocandins are used primarily in the treatment of invasive fungal infections, particularly those caused by Candida species and Aspergillus species. They are often used in patients who are critically ill or who have not responded to other antifungal treatments.
Pharmacology
Echinocandins work by inhibiting the enzyme 1,3-beta-D-glucan synthase, which is responsible for the synthesis of beta-glucan in the fungal cell wall. This leads to a weakening of the cell wall and ultimately the death of the fungus.
Examples
There are currently three echinocandins approved for use in humans: caspofungin, micafungin, and anidulafungin. All three are administered intravenously.
Side Effects
Common side effects of echinocandins include fever, rash, and abnormal liver function tests. More serious side effects can include anaphylaxis and damage to the liver.
External links
- Medical encyclopedia article on Echinocandin
- Wikipedia's article - Echinocandin
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