Amlexanox
Amlexanox structure
Amlexanox synthesis
Amlexanox
Amlexanox is a medication primarily used for the treatment of aphthous ulcers, commonly known as canker sores. It is an anti-inflammatory and anti-allergic agent that works by inhibiting the release of inflammatory mediators from mast cells, neutrophils, and mononuclear cells.
Mechanism of Action
Amlexanox functions by inhibiting the synthesis and release of histamine and leukotrienes, which are chemical mediators involved in the inflammatory response. By blocking these mediators, amlexanox reduces inflammation and promotes healing of the ulcerated tissue.
Uses
Amlexanox is primarily indicated for the treatment of recurrent aphthous ulcers in the oral cavity. It is applied topically in the form of a paste directly to the ulcer, which helps to reduce pain and accelerate healing. The medication is not intended for systemic use and is specifically formulated for oral application.
Side Effects
The most common side effects of amlexanox include:
- Local irritation at the site of application
- Temporary burning or stinging sensation
- Altered taste perception
These side effects are generally mild and transient. Serious side effects are rare.
Contraindications
Amlexanox should not be used in individuals who have a known hypersensitivity to the drug or any of its components. It is also not recommended for use in children under the age of 12 unless directed by a healthcare professional.
Pharmacokinetics
Amlexanox is minimally absorbed into the systemic circulation when applied topically. Its action is localized to the site of application, which limits systemic exposure and reduces the risk of systemic side effects.
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