Abafungin
Antifungal medication
| Abafungin | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | Topical |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | 129639-79-8 |
| PubChem | 6433100 |
| DrugBank | DB04836 |
| ChemSpider | 4938290 |
| KEGG | D02892 |
Abafungin is a broad-spectrum antifungal agent used primarily in the treatment of dermatomycoses. It is unique among antifungal agents due to its mechanism of action, which involves the inhibition of sterol biosynthesis and the disruption of fungal cell membranes.
Mechanism of Action
Abafungin acts by inhibiting the enzyme squalene epoxidase, which is crucial in the ergosterol biosynthesis pathway. Ergosterol is an essential component of fungal cell membranes, and its depletion leads to increased membrane permeability and cell death. Unlike other antifungals, abafungin also exhibits anti-inflammatory properties, which can help reduce the symptoms associated with fungal infections.
Clinical Use
Abafungin is primarily used in the treatment of superficial fungal infections such as tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch). It is applied topically, and its broad-spectrum activity makes it effective against a variety of fungal pathogens, including dermatophytes, yeasts, and molds.
Pharmacokinetics
When applied topically, abafungin is absorbed into the skin layers where it exerts its antifungal effects. The systemic absorption of abafungin is minimal, which reduces the risk of systemic side effects. The drug is metabolized locally in the skin and excreted through natural skin shedding processes.
Side Effects
Common side effects of abafungin include mild skin irritation, redness, and itching at the site of application. These effects are generally transient and resolve with continued use. Severe allergic reactions are rare but can occur.
Related Pages
Gallery
Chemical structure of abafungin
3D space-filling model of abafungin
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
