Chlorphenesin carbamate

A muscle relaxant used in the treatment of muscle pain and spasms

Chlorphenesin carbamate
INN
Drug class
Routes of administration	Oral
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status	Rx-only
CAS Number	886-74-8
PubChem	2724
DrugBank	DB04836
ChemSpider	2622
KEGG	D07150

Chlorphenesin carbamate is a centrally acting muscle relaxant used to treat muscle pain and spasms. It is a derivative of chlorphenesin, which is primarily used as a preservative in cosmetics. Chlorphenesin carbamate is marketed under the trade name Maolate, among others.

Pharmacology

Chlorphenesin carbamate works by depressing the central nervous system, leading to muscle relaxation. It is believed to act on the spinal cord and subcortical areas of the brain, reducing muscle hyperactivity and providing relief from muscle spasms.

Medical Uses

Chlorphenesin carbamate is prescribed for the relief of discomfort associated with acute, painful musculoskeletal conditions. It is often used in conjunction with rest, physical therapy, and other measures to relieve discomfort and improve mobility.

Side Effects

Common side effects of chlorphenesin carbamate include drowsiness, dizziness, and headache. Less common side effects may include nausea, vomiting, and allergic reactions. Due to its sedative effects, patients are advised to avoid operating heavy machinery or driving while taking this medication.

Contraindications

Chlorphenesin carbamate is contraindicated in patients with known hypersensitivity to the drug or its components. It should be used with caution in patients with impaired liver or kidney function.

Interactions

Chlorphenesin carbamate may interact with other central nervous system depressants, such as alcohol, benzodiazepines, and opioids, potentially enhancing their sedative effects. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.

History

Chlorphenesin carbamate was first introduced in the 1950s as a muscle relaxant. It has been used in various countries, although its use has declined with the introduction of newer muscle relaxants with more favorable side effect profiles.

Also see

• Muscle relaxant
• Chlorphenesin
• Central nervous system
• Musculoskeletal disorders