Dimestrol

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Dimestrol is a synthetic, nonsteroidal estrogen of the stilbestrol group that is used in the treatment of menopausal and postmenopausal disorders. It was introduced in 1947 by Dodds et al. and is an analogue of diethylstilbestrol (DES).

Pharmacology

Dimestrol is a synthetic, nonsteroidal estrogen that is structurally related to DES. It has similar effects to natural estrogens in the body, but is more potent and has a longer duration of action. Dimestrol binds to and activates the estrogen receptor, which leads to a proliferation of estrogen-responsive tissues.

Medical uses

Dimestrol is used in the treatment of menopausal and postmenopausal disorders. It can help to alleviate symptoms such as hot flashes, vaginal dryness, and mood swings. It is also used in the treatment of certain types of breast cancer and prostate cancer.

Side effects

Like other estrogens, dimestrol can have a number of side effects. These can include nausea, vomiting, bloating, breast tenderness, headache, or weight changes. More serious side effects can include blood clots, stroke, heart attack, and cancer of the uterus.

Contraindications

Dimestrol should not be used in individuals with a history of blood clots, stroke, or heart attack. It should also not be used in individuals with known or suspected estrogen-dependent tumors.

See also

Estrogens and antiestrogens
Estrogens
ER agonists
* Steroidal: Alfatradiol
Progonadotropins
Antiestrogens
ER 
antagonists
(incl. SERMs

/SERDs

)
Aromatase inhibitors
* First-generation: Aminoglutethimide
Antigonadotropins
Others
* Mixed mechanism of action: Danazol


Estrogen receptor modulators
ER
Agonists
* Steroidal: 2-Hydroxyestradiol
Mixed
(SERMs )
* 2-Phenylbenzofuran
Antagonists
GPER
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